Whatever you cut it with, use a hairdryer to warm it up beforehand.
Never, ever, in your whole life should you try to cut cold plexiglass, lexan, polycarbonate, or any of those other clear plastics. Cut it when it's under 60*F, and it is going to snap and crack as soon as you look at it sideways. Get it over 90*F and the cracking takes some doing. Get it too hot to comfortably hold, and you can pretty much do what you want with it. Get it warm enough, and you can comfortably cut it with a box knife.
By the way, warm means "all the way through". Not just on the surface.