Key items here:
Make sure that your groove volume is bigger than your o-ring cross sectional area.
The extrusion gap (the space between the two parts that the O-ring is being pushed into) needs to be pretty small at 5ksi. Just a few thousandths per side.
You need to have a lead-in chamfer to compress the o-ring. 20 degrees is a good gentle angle.
Process compatible lube is your friend
Your full radius groove is unusual. I assume you are worried about tensile stresses in the part... leave room for the rubber: it does NOT change volume. Just shape!
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