I prefer manual machines to CNC for my home shop. I view CNC as most beneficial for multiples of the same part. Most all of my parts and projects are one off.
Since you are designing a new machines for home shops (?) put some extra engineering work in making them as easy to move as possible. Maybe design machines that can be easily broken down into a few large pieces that can be easily assembled? Built in slots for pallet jacks? Eye screws for lifting? Think about how a machine could be moved around and assembled by a cherry picker? Since you mentioned home CNC machining maybe make a machine that is specifically designed to be converted to CNC?
In my limited experience there is no substitute for weight (mass) when it comes to making parts with good tolerances.
Oh yeah, while you are at it, make them affordable! LOL!