Most of the time, two hands, preferably dry, not too old yet that I can't pick it up and get it in place. I have a padded insert block that locks in position on top of the ways, I use it whenever I am changing chucks. Just for safety, as the chucks can slip. I mark my chucks so they always go in in the same position, I have the key in the top cam-lock, so I hold the chuck in place with one hand and lock one pin with the other. David Best made a very nice chuck holding sled that fits on his ways, probably a better way to go.