I personally stay with a 1/2" endmill or smaller. And at 1/2" I'm usually using a rougher to keep cutting forces reduced.
If you stay within the performance/size envelope of the machines, they work very well.
For example: I was countersinking a screw to be as near perfectly flat with it's surrounding surface. I couldn't go any further with the countersink without leaving a line around the screw head, so I used a 3/8" endmill, zero'd to the surrounding surface on my dro, pulled up .0002" and milled the head of the screw and never touched the surrounding surface.
May not be a big deal to some, but I was impressed.
I also do work in stainless and titanium, but on small (less than 4" square) parts. I buy good cutters and that seems to make a difference with the harder materials, i.e., less stress on the machine.
OP: not trying to threadjack, just answering a question.
Bill