I have used E10 gasoline ever since it came out. This was in all my vehicles, five different outboards, a 1950 Ford 8N tractor, two chippers, two rototillers, a wood splitter, a riding lawn mower, two chain saws and a number of push lawn mowers. I have not had carburetor or injector problems with any of the the engines in all this time. Some of these engines are used a few days a year and stored the remainder of the year. I don't make any particular effort to drain fuel systems prior to storage and I don't use stabilizer.
Regarding fuel ecomony, ethanol provides fewer Btu;s per gallon than does gasoline, 77,000 vs 120,000, so fuel efficiency does drop with increasing ethanol content. A non ethanol gasoline will have better fuel economy than E10 or E15. Whether it is more economical depends on the price differential. Another issue is performance. Generally adding ethanol to gasoline will reduce maximum available hp. Not so much of a problem except for engines used for marine or where much of their use is at full throttle.
It should be noted that octane rating by itself has little effect on economy. It is a measure of a fuel to prevent knocking. Many years ago, when engine compression rations were approaching 12:1, antiknock qualities were important. Higher compression ratios mean a higher thermodynamic efficiency. In fact, the relationship between compression ratio and thermodynamic efficiency is exponential. But unless an engine is specifically designed to use high octane gasoline, higher octane has little bearing on increased performance.
It is difficult to get an octane rating of more than 85 with a straight gasoline blend. More expensive hydrocarbons must be used in the formulation. In the good old days, tetraethyl lead was added to boost octane ratings. Those days vanished due to environmental concerns and justly so. Ethanol has antiknock qualities so blending with ethanol allows the use of less expensive blends of gasoline.
A major reason for fuel system fouling is low quality gasoline. In particular, water in gasoline, due to improper storage. In a straight gasoline formulation, water will settle to the bottom of the fuel tank with small amounts being dissolved in the fuel over time. Adding ethanol to gasoline will allow water to dissolve in the fuel and be carried through the fuel system, potentially causing problems. The Heet used for water removal in fuel in winter is a good example of this property. Heet is either methanol or isopropyl alcohol and has similar properties to ethanol regard adsorption of water. Buy your fuel from a major suppler and a station who does a large volume of sales is a good practice to lessen the chance of getting a tank of bad fuel.
Proper storage of your fuel, once purchased is also a good preventative. Best practice would be to either empty or completely fill fuel tanks prior to long periods of disuse. This will reduce water vapor entering the tank due to thermal expansion and contraction. Totally sealing fuel tanks, when possible also will prevent ingress of water vapor. My outboard tanks sit idle for six months of the year but I can close the vents during that time, My portable tanks can be hermetically sealed when not filling or dispensing.. So far, it's been working for me.