I use them all of the time in my 7x as boring bars, just a little kick to the left for clearance. A boring head holds it square, I would have thought the entire flute would rub.Not really much to it.
If you turn the endmill properly just the tip of one flute will stick out furthest and this becomes your cutting edge.
You can, and I have specially ground endmills for this purpose, but it’s not required.