Aside, I noticed in your drawing, the part shows two nylon tipped thumb screws directly opposite each other, presumably to grip a shaft to prevent rotation or sliding? If so, having the screws 180 degrees apart may not be the best configuration. 60 to 90 degrees apart is considered much better for such an application. This is because when the screws are directly opposite each other, there are the only two points of contact on the shaft, basically pushing against each other. When the screws are offset, they work together forcing the shaft against the wall of the bore giving three points of contact, and over a wider area where the shaft meets the bore. That's why the set-screws are offset not opposite on motor pulleys, gears etc.
Of course this may not apply if there are other factors to consider or be necessary, for light duty applications.
Thanks for the great suggestion .
With the prototype I went with four 90° cross holes just for the "feel". These are thumbscrews, having the left hand turn left and the right hand turn right to tighten seems to come naturally, likewise to release. Having four screws has so far proven to be more than adequate from a holding standpoint. That said, I'm drilling and tapping with a spin indexer so any number of holes is easily possible.