You speak of a high ceiling to allow a "mezzanine deck" or a two story structure in places. Might I suggest air conditioning for the internal portion and a large (3 or 4 ft) in the peak for the nonenclosed portion.
A fan in the peak wouldn't provide a breeze to cool you at floor level, that would be a matter of a smaller fan where you were working. The large fan in the peak would help keep the roof cool(er). Another option would be a "roof over", similar to mobile homes I have seen in north Florida.(a long time ago) Six inches air space to keep the sun off the inner roof works wonders for cooling.
As a rule, I am opposed to airconditioning in general. Especially for a space that has limited use. The first power outage puts that attitude in good perspective. Further, mechanically (electricly) cooling a space with a high ceiling is a killer. Heating is even worse, the heat rises so that the ceiling is toasty but the floor is chilly.
Being so far south of the termite line makes wood framing near the ground less suitable. The afore mentioned footer pads can be filled with SakRete rather than using wooden inserts. Basicly metal and concrete within a couple feet of the ground. I used the old style pressure treated (40 years ground contact in wet location) yellow pine. But that stuff has been outlawed for a while.
Concrete flooring can be laid in in sections, after the building is erected. A good gravel base will compact over time making a still better base as concrete is added for machines. There is a plastic compound sheet that must be placed below the gravel base. Preventin plants from starting roots. . . I don't know the proper term, a friend referes to it as "visquene" from his military time. There are many variables involved in what you are proposing. My inputs are mostly from a theoretical perspective, giving ideas rather than advice.
.