There are products called "barrier cream" that you can put on your hands before working with messy stuff, that form a barrier to protect your skin.
When I used them - oh, 30-40 years ago - there was one kind to protect against water-based soils, and one for non-aqueous soils. The first kind had to wear off; the second kind -- the kind you'd use for grease etc. -- would act as a release agent so when you washed your hands, the muck would (nearly) all slide right off.