Also I am thinking about insulating under the slab.
Rigid foam insulation for under slabs is rated in pounds per square feet, and the stronger you think you need for concrete, the more rigid the foam - more rigidity means less R value... You can go overboard, and spend way more than you have to.
You have a loader that is x feet wide, that can carry a load of z pounds. The load on the front tires will be the load plus at least half the weight of the loader. for instance, if it can handle 2500 lb load and weighs 5000 pounds , and is 5 feet wide, I'd estimate a 5 foot by 10 foot loading zone, or 50 square feet. so for 5000 lbs (2500 plus half of 5000 lbs, you end up with 100 pounds per square foot.
To give yourself some head room specify 100-120 pounds per square foot foam, and specify the pad on to has to be reinforced for 150 pounds per square foot loading. You can do this for your lathe and mill, and determine your loading factor so they don't exceed your floor. Allow that 2 feet around your machine will also carry some of the load as the pad will flex just enough to distribute some of the weight.
I have a 3800 lb lathe on a 4" floor reinforced with mesh (not rebar - dang, but I wasn't there when it was built) and the floor has been fine for me. But I move everything by hand, so I don't have to account for the weight of a compact loader.
update: I just realized that my 4000lb milling machine has higher floor loading: about 180 lbs per square foot.