I developed a nasty rash about three years ago. I thought it was stress induced but it was diagnosed as contact dermatitis by biopsy. The Docs had me start using non-allergenic cleaners, starting with Cetaphil. Ladies like it 'cause it is gentle on their skin, but useless for simple dirty hands let alone grimy or greasy. They said to try Bioderma Autoderm, a lipid based cleanser. Dang, this stuff really works, better than dish soap or the Fast Orange pumice bar soap I had been using for shop hands. Not cheap, but it doesn't take much and it fits the need for an effective, non-allergenic hand clearner. I no longer use any of the orange/pumice cleaners. Still requires water. Some of the major drug stores, like Walgreens carries it, but also available online.