The brass tubes have very sharp ends. If you need a hole in a cork, set it on a piece of wood or similar material, large end down. Take the appropriate sized borer and turn/push it lengthwise thru the cork where you want the hole. When you're through, the borer will be plugged by the cork slug. Use the next smaller size borer, or else the wire from inside the set, to push out the slug. In the case of a rubber stopper, the procedure is about the same, but it helps to lube the borer with glycerine or something similar. Then you can push glass tubing (or whatever) through the hole(s) you've made, put the cork in the neck of your reaction vessel, and proceed with the chemistry.