Couldn't this All be addressed when setting up the Angle plate with the RT correctly the first time in a way that would be very easy at getting you lined up quickly from that point on?
Assuming I set my Angle plate up with the neccessary addition (i.e. mounting bolt holes, locating pin etc...) that lines up with the tailstock what does difference is there in centering the spindle compared with any other setup mounted to a table of a machine that generally allows the material to be adjustable to the spindle on 3 different axis planes?
Here I will agree is possible but that doesn't mean it's an Absolute and could be negated by using a supported angle plate that is stout enough to handle the forces you are asking of it and by making sure it is securely clamped to the table.