Hi Doug, it's great that you're thinking about ventilation for your shop. Proper ventilation is important for any workspace, especially one where you're using flammable substances like kerosene and acetone.
One option is to install a ventilation system that will draw air out of your shop and replace it with fresh air. You can use a high-powered fan, like a centrifugal or axial fan, to create negative pressure that will suck air out of your shop. You'll also need to install ductwork to direct the air outside, and possibly an intake vent to bring fresh air in.
Another option is to install a downdraft table, which is a table with a built-in ventilation system that draws air down and away from your work surface. This can be a good option if you're primarily working on smaller projects.
If you're not comfortable installing a ventilation system yourself, you may want to consider hiring a professional to do the job for you. They can assess your space and recommend the best type of system for your needs.
In the meantime, you could consider using a respirator when working with kerosene, acetone, or other chemicals that produce strong fumes. This will help protect your lungs and reduce the impact of the fumes on your wife.
I hope this helps, and good luck with your shop!