I can't tell what that center hole looks like, but I would start by dialing the part in straight along one axis of the machine.
1. I would pick up the center or the existing hole using a dial indicator in a drill chuck.
2. Using a travel indicator on a mag base or DRO, I would move .75" to the center of one boss spot drill it just enough to make a mark.
3. Use the travel indicator or DRO move 1.5" back to the other boss and spot drill that one the same.
4. I would then use my dial calipers to double check the distance between the spots and that the spots are close to the center of the cast bosses.
5. If it looks good, drill one hole then the other.
You could try to dial into each boss instead of the center hole, but it's a rough looking casting. If you do that still spot each hole and check the distance between the spots before you drill.