No need for Loctite unless you are considering running the spindle in reverse with left hand cutters. You can lock the tang in very securely, put the tang in the vise and the collet holder has some flats for a large wrench. End mills are great for flat bottom holes, although I do most of the material removal with twist drills. On larger holes I have MT2 and MT3 drills from 1/2" through 1 1/2". The Tang is helpful because of the large twisting forces on the arbor, but because it does not have a drawbar, the cutter can grab into the work and pull the drill/end mill forward into the piece. So I am extremely careful when boring with end mills, and mostly use them to do a finishing sizing cut or square the bottom.
One key factor that I find minimizes drill chatter is to use shorter machinist drills. I also always drill a pilot starter hole with a center drill.