Generally, you want to use the material that is suitable for the function of the part. Now, with that being said, I mostly use 6061 for my parts. It machines OK and is usually strong enough for what it is used for. Not only the flat and round, but the tubing as well is 6061. I find that it welds really nice too. So again, to answer your question, you need to use the material that is best for that part to function, then consider the manufacturing processes. Hope this helps.