They made millions upon millions of crankshafts out of cast iron, and I flogged some of them mercilessly without breaking them (broke rods, dropped valves, blew up pistons, but never broke a crank). Doing a stress analysis on a crankshaft is probably out of the question for most hobbyists, as you would need to do a dynamic analysis. The old engineering adage of "When in doubt, build it stout" may apply here, in which case I would recommend 4140 pre hardened. It's relatively cheap, machinable and strong and would give piece of mind. The inline twin would probably be less stressful as long as it has 3 bearings. A lot depends on how beefy the crankshaft is. Long spindly crankshafts without bearings between each cylinder or cylinder bank tend to be a problem anyway.