i'm no expert by any means on the subject:
here is a link to different grades and uses of delrin
http://www2.dupont.com/Plastics/en_US/assets/downloads/design/DELDGe.pdf
nylon machines a little easier but doesn't have the toughness of delrin, at least the grades iv'e been exposed to.
nylon tends to be softer and gummier whereas delrin has a definite shear point not seen when machining nylon
sharp to rounded tools work well and you can remove .100" per side per pass easily with the right tooling on light machines
as far as comparing to other plastics, i'd say that delrin is one of the most stable and all around go to materials for making:
gears, spacers, low speed- no heat bushings, thrust washers, low strength nuts/bolts, non marring pin punches and drifts, bearing/seal installers, bench blocks,
and other uses that don't come right to mind
as long as the part stays relatively cool and the loads are moderate- i put delrin to use!