even plywood has ton of formaldehyde in it, but MDF is pure evil with it's fine dust. even with Dust collection at the source, the fine particles that stay above the TS will linger in the air for hours, and into your lungs.
I try to minimize (read avoid) the use of MDF, and will only use it if I MUST in which case I'll cut it outdoors with a mask on away from the doorways so that the particles won't drift in the shop.
make sure you use a GOOD mask, not the paper ones, and if you see this as a common material that you'll work with often I'd look at alternatives like baltic birch or I'd look into a torsion box assembly if you need surfaces to stay flat (honeycomb) and then you can even use lighter/thinner materials for the top surfaces.