A few things to consider other than just physically bigger.
1. Increased weight, probably looking at an additional 1000 Lbs, good for rigidity, but will make it harder to move/ship.
2. Larger motor, most likely will be a 5 Hp vs. 3 Hp 3 phase, so need the associated 3 phase power to match the increased amperage requirements.
3. Spindle taper may be different than R8, this may be a problem if your current tooling is R8. Top RPM speed may be slightly lower.
4. Everything is bigger, so may need larger end mills and cutters. May need longer arms...
5. Great for larger work, but if you mostly work with smaller projects/sizes, a larger mill can be a bit more cumbersome just because everything is heavier. Would want want power drives at least on the X and Z, and a power drawbar given the height.