The heavy industry shop where I worked for 40 years had reinforced 14" concrete slabs with separaters about every 10'. We went through 2 strong quakes while I was there. Our practice was to keep our smaller lathes on the least # of slabs possible. All of our larger ones were on one piece inertia blocks up to 40' long, depending on the length of the lathe in question & 2', 3' or 7' thick.
As you might guess, the machines on inertia blocks sustained no misalignment or out of level from the quakes. What was surprising though was that neither did the smaller machines. We did go through and re-level & align the lathes about every 15 years or so, to keep up with normal settling of the building on the Columbia River basin, which was never that severe either. There's a lot to be said for a thick reinforced concrete slab.
For most home shop floors a reinforced 6" slab with the machinery bolted to it using adjustable jacking studs, your lathe will be as accurately leveled and aligned after 20 years as the day you installed it.