Consider this: most of us have shops that seem small and crowded. If, not, please skip to the next post.
Space between equipment and walls for access is wasted space. Avoiding that, I set the lathe and mill backing up to the room centerline, and behind them put machines accessible from the other side of the room. In my case, the lathe and my big 9x16” horizontal bandsaw are back to back, with the bandsaw on steel wheels. It’s easily movable for long material or other unusual cuts. The mill is to the left of the lathe, whose spindle axis passes over the mill table region, so very long stock can be used. And if needed, the mill table can support the long stock, using V blocks, bearings, etc. Behind the mill is the big vertical Jet VBS-900 vertical bandsaw…not easily movable, but there is not really any access required behind a Bridgeport.
So my point is, consider putting the equipment in the center of the room, and keeping all the equipment to wall space as useful area.